Adenosine receptor pharmacology book

International union of basic and clinical pharmacology. Adenosine receptors in health and disease springerlink. Adenosine receptors in health and disease handbook of. Adenosine receptors nomenclature as agreed by the nciuphar subcommittee on adenosine receptors are activated by the endogenous ligand adenosine potentially inosine also at a 3 receptors. Adenosine receptors in health and disease handbook of experimental pharmacology. The role of adenosine receptors in psychostimulant. Most atp is hydrolyzed to adp, which can be further dephosphorylated to amp. Subsequent sar work on this novel heterocycle led to the identification of the triazoloquinazoline, cgs 15943 54, a potent adenosine receptor antagonist with.

Adenosine is an important cardiovascular medicine used in the treatment of arrhythmias. This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of parkinsons disease. A3 adenosine receptors from cell biology to pharmacology. Borea pa 1, gessi s1, merighi s1, vincenzi f 1, varani k 1. Coverage includes data from studies of theoretical, molecular, and cellular pharmacology, signal transduction, read more. Adenosine a3 receptors are g proteinlinked receptors that function in physiology and intracellular signaling and are involved in inflammatory responses and mediating cell proliferation and cell death. Pharmacology of adenosine receptors and their signaling role in immunity and. Adenosine receptors and inflammatory and autoimmune diseases. However, the drug also comes with a range of significant adverse effects and warnings. Adenosine a2b receptor antagonists tocris bioscience. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression.

Novel neuroprotection by caffeine and adenosine a2a receptor antagonists in animal. The techniques of molecular pharmacology have been extensively used to delineate purinergic receptor function, resulting in the identification of several receptor subclasses that subserve discrete physiological functions table i. Pharmacological probes for a1 and a2 adenosine receptors in vivo in feline. Effects and therapeutic applications of adenosine receptors on tissues and organs. Pharmacology of adenosine receptors and their signaling role in immunity and inflammation chapter pdf available july 2014 with 116 reads how we measure reads. Home pharmacology 7tm receptors adenosine receptors adenosine a 2b receptors adenosine a 2b receptor antagonists adenosine a 2b receptor antagonists cat. Pharmacology of adenosine receptors and their signaling role in immunity and inflammation.

Adenosine receptors are a family of gpcrs containing four subtypes. Atp is the primary energy source in cells for transport systems and many enzymes. Pharmacology of adenosine receptors and their signaling role in. Throughout the 1990s and 2000s adenosine receptors were cloned, and the. Adenosine is a naturally occurring purine nucleoside that forms from the breakdown of adenosine triphosphate atp. Adenosine receptors ar are a family of gprotein coupled. Crystal structures for the antagonistbound 14, 36, 58, 66, agonistbound 5354, 79 and g proteinbound a 2a adenosine receptors 12 have been described.